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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Functional nanoparticles for plasmonic biosensors
 Přítulová, Marie ; Salyk, Ota (referee) ; Vala, Martin (advisor)
This thesis aims to prepare functional gold nanoparticles (AuNPs) and use them in conjunction with a surface plasmon resonance (SPR) biosensor for highly sensitive detection of carcinoembryonic antigen (CEA). In this work, preparation of colloidal AuNPs was investigated and a three-step synthesis was optimized to yield spherical nanoparticles with a diameter of about 100 nm and smooth surface. The synthesized AuNPs were functionalized by a self-assembled monolayer of carboxy-PEG alkanethiols and streptavidin and characterized by UV/VIS spectroscopy and -potential method. Finally, the functionalized AuNPs were employed in sandwich assay for the sensitive detection of CEA and it was demonstrated that they can enhance sensor response to CEA by a factor of 100 compared to the direct detection of CEA.
Detailed record
Functional nanoparticles for plasmonic biosensors
 Přítulová, Marie ; Salyk, Ota (referee) ; Vala, Martin (advisor)
This thesis aims to prepare functional gold nanoparticles (AuNPs) and use them in conjunction with a surface plasmon resonance (SPR) biosensor for highly sensitive detection of carcinoembryonic antigen (CEA). In this work, preparation of colloidal AuNPs was investigated and a three-step synthesis was optimized to yield spherical nanoparticles with a diameter of about 100 nm and smooth surface. The synthesized AuNPs were functionalized by a self-assembled monolayer of carboxy-PEG alkanethiols and streptavidin and characterized by UV/VIS spectroscopy and -potential method. Finally, the functionalized AuNPs were employed in sandwich assay for the sensitive detection of CEA and it was demonstrated that they can enhance sensor response to CEA by a factor of 100 compared to the direct detection of CEA.
Detailed record

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